UNLOCK: Unlock this item by beating Delirium on The Void floor with ??? Part Two Second Knife Piece. Caves 2: 1 Boss Item + 2 Soul Hearts, Depths 1: 4 Soul hearts. in a small boss room), UNLOCK: Unlock this item by defeating Greedier Mode with Lilith, Gives you a 100% chance to find an Angel Room on every valid floor after defeating the boss, Doesn't spawn an angel room on any floor where it is normally not possible to find one (e.g. yellow, white, triangle, The three heart containers are pre-filled with red hearts, UNLOCK: Unlock this item by beating the Chest with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, real platinum god, the lost item pool, Enemy projectiles will now slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this item by beating Dark Room with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, starting, bloody, white, bandages, lazarus rags, Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms, UNLOCK: Unlock this item by beating Satan with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, There are some 300 gameplay changes, according to YouTuber IsaacGuru. HARDHARD. ?, Satan and The Lamb as Tainted Eden, Each brand new room, this trinket has a chance to transform into a copy of a random passive item, which gives you the effect for the duration of this room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eden, Gives a small chance to spawn a friendly Bony when clearing a room, which will throw bones at enemies until it takes enough damage to die, Can be either the regular white Bony or the black variant, UNLOCK: Unlock this trinket by defeating Isaac, ?? Doing so will cause it to increase in size, and also increase their damage and the damage of the burst tears, Once a tear is fed 5 times, it will immediately burst, Tears in the burst will deal half the damage the main tear would have, Added as part of the Afterbirth+ Booster Pack #4. Midnight Snack = +1 flat damage, +1 luck. The laser hits up to 13 times if an enemy stays inside it for the duration, Has a chance to drop from the Envy and Super Envy miniboss fights, Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss, * item room, treasure room, item room pool, red, lips, white, eyes, UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss, *, black, white, face, eyes, mouth, golden chest pool, +10% chance of a devil/angel room opening while held, A second Pentagram will give an extra +5% chance, Counts as 1 of 3 evil items needed towards the Leviathan transformation, Item Pool: Boss Room, Curse Room, Devil Room, Demon Beggar, Crane Game, * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item, PAC1F1ST. Spawns another Vurp! Small critique: I don't think spirit sword is very good, i think fool's gold is a much better unlock. For everything it increases by 1 coin * the number of purchases, The max price of an item is always 99c with this item, Works with Keeper's Box and the Member Card extra shop, Most spider enemies no longer target or deal contact damage to Isaac, This is very similar to a Skatole for spiders instead of flies, Continuously firing or charging tears for 3 seconds causes Isaac to fart and drop a Butt Bomb, Only 1 Butt Bomb can be dropped per charge, so you'll need to stop firing then start again to drop another one, Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time, *, yfront, y-front, underpants, underwear, white, grey, gray, no 2, number two, number 2, no two, Transforms Isaac's tears into a wide arc shape which doubles their size and hitbox, *, flat, white, grey, gray, blue, drip, water, eyes, This item turns all doors that require a key into doors which need a coin to enter instead, This affects shops, item rooms, libraries, double locked doors, key blocks, chests and other key doors, Changes the appearance of doors and objects that this item works on to show a coin slot instead of a keyhole, Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop, *, grey, gray, metal, slot, rectangle, silver, Gives you a random item at the start of your next run (You need to start a fresh run to receive the item), Important progression items such as Key Pieces or the Mom's Shovel pieces cannot be given by Eden's Blessing, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eden, When used, can be thrown at enemies to capture them (similar to a Pok Ball), After capturing an enemy, the next use of the Friendly Ball will re-spawn the same enemy as a friendly companion which will attack other enemies, The companion will persist between rooms and floors until it dies by taking enough damage, Walking over the thrown ball after capturing an enemy will immediately recharge it, *, pokemon, grey, gray, blue, deathstar, circle, When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head, Luck-based items such as Holy Light are applied to each tear individually, Gives Isaac a familiar Gurdy that will charge around the room dealing contact damage to enemies, The Gurdy is charged by holding down the fire button and letting go. Demo man unlocks a card that can instantly kill any enemy, including end bosses. Great list! It can spawn familiars you haven't unlocked yet! His body can be controlled and spews blood nearby, Tears fired by the head do a flat 3.5 damage and don't scale, REPENTANCE - Scissors has been redesigned. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. Basement 1, Cathedral, Sheol etc. Bombs, keys, cards, runes and batteries have a 20% chance, Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks, REPENTANCE - Added to the Secret Room pool. Killing a petrified enemy will freeze it. REPENTANCE - Using this book once before the boss dies, causes the boss item on the current floor to become a devil deal instead, where it will cost heart containers to pick up. The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. As you slide more elements, the others will be eliminated and the others will be rolled softly 8 Spelunker Hat. Tbh, these unlocks really spice up runs and are worth unlocking first on every B-side character (maybe except for Haunted Chests), but the Crane Game is the strongest one. Curse Rooms and Blood Donation Machines don't trigger this effect, Items with a price will spawn the extra item free of charge (i.e. Works in shops and devil deals as well, allowing you to take them for no cost. Takes more shots before breaking, Bomb poop - Throws a butt bomb that explodes after 2 seconds, UNLOCK: Unlock this item by defeating Delirium as Tainted Blue Baby, Allows you to quickly double tap a shoot button to sneeze on nearby enemies, dealing x1.5 your tear damage and pushing them back slightly, If an enemy is pushed into a wall or object it takes 10 damage, UNLOCK: Unlock this item by defeating Delirium as Tainted Azazel, Bombs become spectral and can now pass through objects, Bombs spawn a friendly white soul, which will hunt down other enemies, dealing contact damage which scales with your tear damage, After 10 seconds the white soul explodes dealing 7 damage to nearby enemies. Glitched Crown is in this list as the strongest among them once you learn how to pick out the item you want consistently. ?, as they cannot gain red heart containers (except for counting towards the Spun transformation), REPENTANCE - Adrenaline now grants an increasingly higher damage bonus the more empty heart containers Isaac has, * Adderline, pink, syringe, needle, injection, Isaac gains electric tears, which fire 1-2 sparks of electricty in random directions upon hitting any object or enemy, The electricity will chain between nearby enemies, The electricty deals half of your normal tear damage, Tear effects will still apply to your electricty sparks in a lot of cases. Based loosely on the Steam Workshop mod created by Extreme Ninja Home Makeover with changes by Edmund McMillen, *, lepracy, leprasy, leprosy, pink, red, bloody, lump, Gives you a random Harbinger familiar that changes every 10 seconds, Each harbinger behaves differently, based on any of the original 5 horsemen bosses, REPENTANCE - The harbingers will also randomly spawn their relevant Locust variant. poison effect for Pestilence, Added as part of the Afterbirth+ Booster Pack #3. Doing this will cause this Golden Battery to reappear somewhere else on the floor, UNLOCK: Unlock this by defeating Mega Satan as Tainted Forgotten, Spawns similar to regular troll bombs and cannot be picked up, However, they will explode forever instead of disappearing, The Safety Scissors trinket will turn this into a gold bomb, When picked up, will respawn again at a random location in the room, Every time you pick up a golden penny it has a 5% chance to disappear completely, UNLOCK: Unlock this by defeating Mega Satan as Tainted Keeper, Once picked up, the gold heart will drop money on the floor the next time Isaac loses a heart, UNLOCK: Unlock this item by beating challenge #21 (XXXXXXXXL), Takes three hits to deplete and can be refilled with red hearts, but disappears forever when depleted, UNLOCK: Unlock this item by unlocking the Forgotten character. If you touch an enemy in that time, Isaac will pick it up and slam it on the ground, killing it and sending a shockwave around the impact, In the brief period while holding the enemy you can move a target to decide where it lands, Actually does work on bosses! UNLOCK: Unlock this item by beating Greed Mode with ??? Deals 45 damage to enemies it lands on. With +0.5 Damage being one of the possible random stat rewards, this item is really the only Damage Up you'll need for the entire run. if you have 99 coins it will create 3 x Quarters, 2 Dimes and 4 Pennies. Throwing this at the Great Gideon boss will trigger a special animation and reveal a crawl space containing several chests and items! syringe, needle, injection, purple, grey, gray, Causes Isaac to shrink in size (including hitbox slightly), Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms, * item room, treasure room, item room pool, mushroom, blue, spotted, Adds several instances of The Bible item into all item pools. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. golden, yellow, glow, A familiar that follows Isaac and blocks any shots that hit it, If a projectile is blocked by Dry Baby, he has a 10% chance to activate the Necronomicon effect, dealing 40 damage to the entire room, The chance to activate the effect is not changed by your Luck stat, * item room, treasure room, item room pool, dry baby is best baby, northernlion, fat skeleton, Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. No longer drops black hearts like it used to. The achievement 'Sumptorium' is unlocked by defeating Delirium as Tainted Eve, When used, this will retreive the Tainted Forgotten's skeleton back to its owner's hands from any distance, Tainted Forgotten's Birthright effect. You may see more or less than this on the Found HUD overlay, however this number varies based on your other damage increasing items. Every 45 seconds, a ticking will begin, and after 5 seconds, Isaac will take 1/2 heart of damage. Health down effects still only remove 1 heart, Eve - Whore of Babylon and Dead Bird effects are always active, Samson - Bloody Lust can gain 4 more damage boosts, for a new max total of +14 Damage, Azazel - His beam becomes much wider, no effect on damage. white, square, When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations), REPENTANCE - Book of Secrets now avoids giving mapping effects that the player already has. Unlocked from the 'Dedication' achievement (participate in 31 dailies in a row), I'm Drowsy - Slows all enemies for the rest of the current room, I'm excited!!! Taking it will cause Mom's Shadow to spawn and chase you. ), *, money, silver, grey, gray, steam, smoke, cent, Everytime you pick up a coin, you have a 25% chance to spawn a key, *, white, grey, gray, coin, cent, money, cash, When picking up a coin, you have a chance to automatically gain one more coin, UNLOCK: Unlock this item by playing the shell game in the arcade 100 times, *, yellow, golden, coin, cent, money, cash, sparkle, When you enter a boss room, immediately remove 15% health from the boss and restore 1 red heart, This trinket cannot be dropped by holding the drop key or picking up other trinkets. Toda. Doesn't include Curse Room doors or spiked rocks, Tears can be controlled mid-flight using the directional keys, In addition to regular tears, Isaac will sometimes fire extra spectral tears that orbit around him, Fully heals all your red heart containers, Isaac now emits a large light aura that damages nearby enemies 5 times per second while touching it, The visual effect is similar to the effect given to tears by the GodHead item, The aura deals more damage towards the center, ranging from 0.75 at max range to 4 damage when touching Isaac, In addition to normal tears, Isaac now also fires a set of 4 quadshot tears with a slowing effect, The quadshot tears deal 1.5 damage each and do not scale with your damage upgrades, Upon taking damage, you have a chance to dislodge the spider from your face. When used, this item will rewind time and put you back in the previous room, in the same state you were in at that moment, This means any damage taken or consumables used in the current room will be reset back to the previous state, Can be used to check the contents of an Item Room without affecting Planetarium spawn chances, Glowing Hour Glass has no cooldown, but can only be used 3 times per floor (as of 1.7.9 update), Recharge time: None (Max 3 use per floor), Item Pool: Item Room, Shop, Greed Mode Item Room, * hourglass, hour glass, egg, timer, blue, brown Glowing Hourglass, Gives Isaac a large white halo around him, that deals a bit of damage to any enemies in contact with the ring, Every time an enemy bullet enters the ring, there is a chance it will reflect a homing tear back at the enemy, Coins have a 10% chance to be replaced with Sack. If used in a room with no enemies, Dark Esau will instantly spawn, Will chain up to two targets if you have Car Battery, if only one valid target is present it will be chained for twice the duration, UNLOCK: Unlock this item by defeating Delirium as Tainted Jacob, Rerolls all pedestal items, lowering all their internal item IDs by 1, For example: Brimstone's ID = 118, so it would be rerolled into Dead Bird (ID = 117), Sad Onion (ID = 1) will reroll into nothing, There are some gaps in item IDs which are skipped if no item exists, or will reroll into unexpected items if hidden items are present at that ID. Also works for opening Spiked Chests and Mimic Chests without taking damage, When used, this item restarts the game and places you back on the first floor with all your currently collected items, similar to doing a Victory Lap, Allows angel rooms to be found in the new run if a devil deal was taken in the first run, In Greed Mode and while playing as Tainted Keeper, this item costs 99 coins instead of 15. A slow pulsing outline HUD effect appears for cards that would be buffed by Tarot Cloth, To see the full list of Tarot Card effects, check out the Mechanics > Tarot Cloth page, Every time you take damage, 10 high damage tears are fired in a circle around you (similar to the Tammy's Head effect), Tear damage is equal to Isaac's tear damage + 25 flat damage, Additionally, has a chance to activate the Anemic effect when taking damage for 2 seconds, Similar to Tammy's Head, this item synergizes with a lot of items (i.e. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor. Hook Worm, Wiggle Worm etc. You can't use the Red Key to leave this room, The Red Key can be used to open the secret room in the Home floor, which is the method for unlocking alternative 'Tainted' characters, UNLOCK: Unlock this item by opening Mom's Box in the Home floor, Item Pool: Secret Room, Red Chest, Curse Room, Key Beggar, Mom's Chest. The anticipated final DLC to The Binding Of. The fastest, easiest way to get the five Gulp! Based on the Steam Workshop mod (originally called Water Balloon) created by HiHowAreYou, UNLOCK: Unlock this item by picking up the Blood Clot item 10 times, Isaac's tears slow down over time while moving across the room, and upon stopping completely or hitting an object will burst into 8 smaller tears which fire in all directions, This item will also allow you to 'feed' a tear with other tears. ?, Satan and The Lamb as Tainted Isaac, Every time you enter a brand new room, you have a chance to get a random one-time use Dice (e.g. (Repentance) 3:39. the binding of isaac repentance 3,000.000% (save file) franco garcia. Increases the maximum heart limit to 18. ?, Paralysis, Retro Vision, I'm Excited, While held, gives you an orbital that blocks enemy shots and deals contact damage equal to 3.5 per tick, While the active key is held down, Isaac gains +0.5 Speed and all of your orbitals spin faster and deal more damage, Orbital damage is equal to 1.5 x OrbitalDamage + 6 while this effect is active, On death enemies now fire tears in random directions, which can damage other enemies, The amount of tears created by this effect depends on the total health of the enemy killed. Cube of Meat after defeating a Horseman, REPENTANCE - It is now possible to see items again that have been rerolled away, preventing emptying the item pool and 'Breakfasting', REPENTANCE - Chaos now assigns a "weight" to item pools based on how many items are in the pool. The main purpose of the Cracked Key is to unlock Tainted character in the Home floor without needing to find the Red Key. the eternal hearts that drop in angel themed super secret rooms, All heart drops from Ace of Hearts will be Black Hearts, UNLOCK: Unlock this item by beating Satan with Azazel, *, black, devil, pointy, daemons tail, demons tail, demon tail, Dying in a sacrifice room while holding this trinket will unlock The Lost character, After The Lost is unlocked, dying anywhere with this trinket will bring you back to life as The Lost and the trinket will be deleted, When playing as Tainted Lost, you don't swap to being regular Lost, it simply acts as an extra life, UNLOCK: Unlock this item by beating Dark Room with Isaac, Everytime you pick up a coin, you fart, inflicting poison damage to nearby enemies, Greatly increases the chance of coins dropping from poops, Tears now move forwards at right angles, shifting left and right across the room, Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal, Your tears now whip across the room at a very high shot speed, Shot speed gives your tears more effective range, but doesn't increase your range stat directly, Has a 22.22% chance to respawn with 3 Soul hearts as Blue Baby when you die, UNLOCK: Unlock this item by beating Satan with Lazarus, Everytime Isaac takes damage, one blue fly will spawn, * , the lost item pool, green, red, bloody, dead, Isaac's tears have a chance to poison enemies, The poison effect leaves a damage over time, which deals 4 or 6 damage per tick, The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time, Isaac now has a chance to make a spectral and piercing tear, The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time, While held, this trinket gives a random mushroom effect each room, Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass, *, ping, pong, paddle, grey, gray, mushroom, While at 1/2 a red heart of health, you gain a Little Steve familiar that follows you and shoots homing tears, REPENTANCE - Umbilical Cord now has a high chance to spawn a Gemini familiar for the room when Isaac takes damage. The locust fly will do different things for each harbinger - e.g. Shotgun is one of the strongest weapons in the game that can take out a super mutant in two to three shots. This is the strongest Shop item in the entire game. It's an Angel Room version of Brimstone/Maw of the Void, which is as good as it sounds. Taking a Devil deal breaks the cross and prevents the damage up next floor, Taking free pickups such as Black hearts in the Devil room also count, UNLOCK: Unlock this item by defeating The Beast as Judas, When you die, you turn into a ghost with 1/2 a red heart and flying, that is chained to your body for 10 seconds. A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. shop room pool, shop item pool, cross, brown, Upon use, gives +2 damage up which lasts for the current room, x1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers), Increases your chances of getting a devil/angel room by +12.5%, REPENTANCE - The effect stacks if used multiple times, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, starting I was trying to remember what unlocked crane game. - Tears will shoot diagonally for about 60 seconds. If you haven't unlocked Holy Mantle for The Lost yet, you won't gain the effect after touching a white fire so be careful! Any Tarot card or rune on the floor or current held when picking this item up will change into a pill, Dice Shard counts as a card and will be converted, UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball, * shop room pool, shop item pool, brown, purple, * boss room pool, boss room item, red, wedge, purple, triangle, The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only, * boss room pool, boss room item, red, blob, circle, spot, * boss room pool, boss room item, grey, gray, Enemies touching placed bombs take 16 damage, Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies, REPENTANCE - Hot Bombs now have greatly increased contact damage (increased from 1 to 16), and passively grants Isaac immunity to fire, * item room, treasure room, item room pool, fire, orange, flame, face, Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick, There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies, Exploding tears deal damage * 2 + 22 per tick, The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time, * item room, treasure room, item room pool, fire, flame, orange, back, ball, burning, When picked up, and at the start of each floor this rerolls all your current items, giving you a new item to replace each of the ones you had, Also rerolls all your stats at the same time, giving a random flat modifier that changes each time, Doesn't affect important items such as Polaroid, Negative and Key Pieces, UNLOCK: Unlock this item by beating Boss Rush with Lazarus, * secret room pool, mondrian, painting, yellow, blue, red, white, Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac, The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time, An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool), * devil pool, devil room pool, devil deal, grey, gray, fist, glow, Immunity to all floor curses (e.g. To unlock Tainted character in the entire game will trigger a special animation and reveal a space! 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